• Platelet CD40L mediates thrombotic and inflammatory ...

    Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood, 2010. Louis Boon. Oliver Soehnlein. Oliver Soehnlein. Oliver Soehnlein. Pieter Goossens.

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  • Red blood cell aggregation in nephrotic syndrome

    Red blood cell aggregation in nephrotic syndrome. Red blood cell (RBC) aggregation induced by fibrinogen is a major determinant of the non-Newtonian flow behavior of human blood and has been suggested as a possible contributing factor for thrombogenesis. Given the elevated fibrinogen levels and the high incidence of thrombotic accidents in

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  • Thrombotic Thrombocytopenic Purpura: Beyond Empiricism and ...

    Although the pathogenesis of thrombotic thrombocytopenic purpura was largely unknown, the prognosis dramatically improved since the 1970s, when plasma infusion and plasma exchange began to be used for its treatment, 4. x 4. Bukowski, R.M., King, J.W., and Hewlett, J.S. Plasmapheresis in the treatment of thrombotic thrombocytopenic purpura. Blood.

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  • Computational Modeling of Blood Clotting: Platelet ...

    Thrombosis, which is the formation of blood clots within vessels of the circulatory system, is the proximal cause of most heart attacks and of other severe cardiovascular problems such as ischemia and angina. The two main components of the thrombotic process are platelet aggregation and coagulation. Platelet aggregation involves processes of cell-cell and cell-substrate

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  • Probing blood cell mechanics of hematologic processes at ...

    Blood cells circulate in a dynamic fluidic environment, and during hematologic processes such as hemostasis, thrombosis, and inflammation, blood cells interact biophysically with a myriad of vascular matrices—blood clots and the subendothelial matrix. While it is known that adherent cells physiologically res Lab on a Chip Emerging Investigators

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  • Red cell aggregation in blood flow | SpringerLink

    Red cell aggregation in blood flow. II. Effect on apparent viscosity of blood. ... Blood cell aggregation in thrombotic processes. ... L., Klose, H.J., Volger, E.: A counter-rotating "rheoscope" chamber for the study of the microrheology of blood cell aggregation by microscopic observation and microphotometry. Microvasc. Res.6, 366 ...

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  • Whole Blood Viscosity and Arterial Thrombotic Events in ...

    tants such as fibrinogen), and red blood cell aggregation and deformability (16). In contrast to serum or plasma viscosity, measurement of WBV does not involve separa-tion of the constituents of blood, and therefore most closely resembles the natural rheologic conditions in the bloodstream. Whole blood is a non-Newtonian fluid,

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  • Endothelial progenitor cells inhibit platelet function in ...

    Endothelial progenitor cells (EPCs) play a pivotal role in vascular biology and homeostasis, as they enhance the process of re-endothelialisation and neo-vascularization of injured and ischemic tissues [1-5].Interactions of EPCs with vascular and blood cells can largely influence their biological activity and impact their recruitment to target tissues.

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  • Pro-Thrombotic Activity of Blood Platelets in ple ...

    cells Review Pro-Thrombotic Activity of Blood Platelets in ple Sclerosis Joanna Saluk-Bijak *, Angela Dziedzic and Michal Bijak ... as an increased adhesion and aggregation and is accompanied by the formation of ... Blood platelets adhering to endothelial cells support the process of diapedesis and leukocyte infiltration into the affected ...

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  • Hemostasis | Boundless Anatomy and Physiology

    Hemostasis is the natural process in which blood flow slows and a clot forms to prevent blood loss during an injury, with hemo- meaning blood, and stasis meaning stopping. During hemostasis, blood changes from a fluid liquid to a gelatinous state. Steps of Hemostasis

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  • Red cell aggregation in blood flow | SpringerLink

    Red cell aggregation in blood flow. II. Effect on apparent viscosity of blood. ... Blood cell aggregation in thrombotic processes. ... L., Klose, H.J., Volger, E.: A counter-rotating "rheoscope" chamber for the study of the microrheology of blood cell aggregation by microscopic observation and microphotometry. Microvasc. Res.6, 366 ...

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  • Red blood cells: the forgotten player in hemostasis and ...

    New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review summarizes the most recent research that describes the involvement of RBCs in hemostasis and thrombosis.

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  • Effect of Red Blood Cells on Platelet Activation and ...

    In straight vessels, the presence of red blood cells (RBCs) is known to push platelets toward walls, which may affect platelet aggregation and thrombus formation. However in tortuous vessels, the effects of RBC interactions with platelets in thrombosis are largely unknown.

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  • Thrombosis and Circulation Open Access Cimmino et al., J ...

    blood cells, mainly involved in venous thrombosis [20]. As final effect, coagulation is promoted in animals model [17,20] as well as in humans [21,22]. The traditional role of platelets in the haemostasis process Platelets are anucleate small cell-fragments derived from megakaryocytes and free circulating in the blood in a resting

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  • Probing blood cell mechanics of hematologic processes at ...

    Blood cells circulate in a dynamic fluidic environment, and during hematologic processes such as hemostasis, thrombosis, and inflammation, blood cells interact biophysically with a myriad of vascular matrices—blood clots and the subendothelial matrix. While it is known that adherent cells physiologically res Lab on a Chip Emerging Investigators

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  • Red blood cells: the forgotten player in hemostasis and ...

    New evidence has stirred up a long‐standing but undeservedly forgotten interest in the role of erythrocytes, or red blood cells (RBCs), in blood clotting and its disorders. This review summarizes the most recent research that describes the involvement of RBCs in hemostasis and thrombosis.

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  • Schistocyte - Wikipedia

    A schistocyte or schizocyte (from Greek schistos for "divided" and kytos for "hollow" or "cell") is a fragmented part of a red blood cell.Schistocytes are typically irregularly shaped, jagged, and have two pointed ends. Several microangiopathic diseases, including disseminated intravascular coagulation and thrombotic microangiopathies, generate fibrin strands that sever red blood cells as they ...

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  • Unlocking the mystery behind blood clots | Penn State ...

    Coagulation of platelets is key to stopping blood loss from a cut or wound, but overactivation of this process — thrombosis — can lead to deadly blood clots, heart attack or stroke. The new findings take researchers one step closer to developing new anti-thrombotic drugs without the serious side effects that can cause fatal bleeding.

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  • The involvement of platelets in non-thrombotic processes

    non-thrombotic processes C. P. Page The platelet, the smallest blood element, has tended to be considered only in the context of physiological homeostatic mechanisms and pathological conditions such as thrombosis and related cardiovascular diseases. However, it now seems that this view is too limited.

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  • Inflammation, Ch 3 Porth Questions and Study Guide ...

    Inflammation, Ch 3 Porth. STUDY. PLAY. ... a relatively large phagocytic white blood cell that circulates in the bloodstream and has a single ovoid nucleus. once these cells migrate into the tissues from the blood, they become macrophages: ... contibute to initiation of healing process 4) typically arrive at the inflammatory site 24 hours or ...

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  • phlebotomy (CH 6) The Circulatory System Flashcards | Quizlet

    The vascular pathway that carries oxygenated blood from the heart, along with nutrients, to all the cells of the body and then returns the blood to the heart, carrying carbon dioxide and other waste products of cellular metabolism.

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